The Framingham Cognitive Aging Study boasts arguably the richest database of its kind, with up to 45 years of prospective health and lifestyle measures, along with available genetic and other biomarkers to relate to brain health. The longitudinal assessment of brain health includes an extensive battery of neuropsychological testing as well as neuroimaging via MRI. More recently, the assessment of cognitive performance has also included digital capture, starting with voice (2005) and written performance (2011), positioning this project for the current goal of moving forward the Framingham e-Cognitive Health Study (FeCHS). The study uses 45 years of existing health related data to validate new e-health measures against known gold standards in order to build and implement an e-digital health platform that integrates use of wearable/mobile and smart home technologies, transforming our understanding of how the brain ages. Cognitive decline with age does not have to be inevitable. The FeCHS provides a transformative platform designed to catalyze groundbreaking discoveries for cognitive impairment prevention, inform policies for reducing the economic cost and healthcare burden generally associated with progressive dementing disorders, such as Alzheimer’ disease, and identify determinants of sustained lifelong cognitive health.